People
The Exercise Immunology and Health Lab brings together researchers from sports medicine, immunology, nutrition science, data science, clinical research and practice.
Christian Puta
Head of the Exercise Immunology and Health Lab · apl. Professor for Sports Medicine and Health Promotion
christian.puta@med.uni-jena.de
As head of the Exercise Immunology and Health Promotion Laboratory, Christian Puta is guided by the conviction that physical activity is one of the most powerful and universally accessible modulators of immune function, resilience, and long-term wellbeing. The laboratory translates mechanistic insights from exercise immunology into evidence-based strategies that empower individuals — from healthy populations to those recovering from infection or managing infection-associated chronic illness.
Christian Puta’s research investigates the immunological and physiological consequences of exercise and infection, with a particular focus on post-exercise recovery processes. A central aim is the development of models describing dysregulated immunological and metabolic recovery — including post-exertional malaise (PEM) as a defining feature of infection-associated chronic illness such as Long COVID and ME/CFS. Building on wearable sensor technology and standardised exercise testing, he develops monitoring and rehabilitation strategies that account for individual immune phenotypes and the risk of exertion-induced symptom exacerbation.
Bio
- Venia Legendi in Sport Science, Sports Medicine & Health Promotion, Friedrich Schiller University Jena (12/2017)
- Director of the Center for Interdisciplinary Prevention of Occupational Diseases (03/2019)
- Member of the Center of Sepsis Control and Care, University Hospital Jena (08/2023)
- Award of the title apl. Prof. for Sports Medicine and Health Promotion, Friedrich Schiller University Jena (08/2023)
- Interim Director, Department of Sports Medicine and Health Promotion, Friedrich Schiller University Jena (04/2024)
- Affiliated with the Department of Internal Medicine IV, University Hospital Jena (since 05/2024)
- Corporate academic status of an appointed professor, Department of Health Promotion, Friedrich Schiller University Jena (02/2025)
- Member Medical Faculty Council, University Hospital Jena (04/2025)
Publications
Claudio Troßler
Student Assistant · M.Sc. Student
Short biography to be added.
Franziska Ziegler
Student Assistant · M.Sc. Student
Master’s student in sports science and student assistant. Currently working on the development of an algorithm for the sonographic quantification of exercise-induced muscle damage (e.g. muscle fiber tears) and subsequent recovery processes. The aim of the work is to improve sports medicine musculoskeletal ultrasound diagnostics and return-to-play decision-making. Also engaged in teaching within the department.
Marc Gabriel
Research Assistant · PhD Student · SynoSys.PC project
Data scientist with a background in computer science. Works on data-driven approaches to better understand the immunological mechanisms underlying post-exertional malaise and postural orthostatic dysregulation in infection-associated chronic illness (e.g. Long COVID), using wearable-based methods to analyze physiological data (sleep, heart rate and physical activity).
Teaching
- Development of research-based digital tools for teaching and practice, including the Immunenotes apps and dashboards.
Publications
- Puta C, Reuken P, Katzer K, Gabriel M, Dudziak D, Stallmach A (2025). Exercise Snacks. Ärzteblatt Thüringen 11: 24-28. aerzteblatt-thueringen.de/pdf/thu2511_024.pdf
Marco Herbsleb
PostDoc · Clinical Exercise Physiology
Marco Herbsleb is a sport scientist and postdoctoral researcher in clinical exercise physiology at the Exercise Immunology and Health Lab, Friedrich Schiller University Jena. He also works as a postdoctoral researcher at the Department of Psychosomatic Medicine and Psychotherapy, Jena University Hospital. His research focuses on cardiorespiratory fitness, autonomic cardiovascular regulation, and physiological responses to exercise in healthy individuals and clinical populations. Using standardised exercise testing, heart rate and heart rate variability analysis, and functional performance assessments, he investigates exercise capacity and individual responses to physical exercise. A particular focus lies on the mechanisms underlying reduced exercise capacity and exercise intolerance in people with psychiatric disorders, as well as on the potential of individually tailored exercise interventions. His more recent research explores the relationships between physical activity, cardiorespiratory fitness, brain health, cognition, and neuroplasticity in older adults and endurance-trained individuals. The overarching aim of his work is to translate physiological insights into evidence-based assessment and exercise interventions.
Office hours
General office hours: By appointment via email.
BAföG consultation for the B.Sc. Sport Science – Performance & Health programme: By appointment via email only.
Research interests
- Clinical exercise physiology and exercise testing
- Cardiorespiratory fitness and autonomic cardiovascular regulation
- Heart rate variability and physiological responses to exercise
- Exercise capacity and exercise therapy in people with psychiatric disorders
- Relationships between physical activity, fitness, brain health, cognition, and neuroplasticity
Bio
- Diploma in Sport Science (Prevention and Rehabilitation), Department of Sports Medicine and Health Promotion, Friedrich Schiller University Jena
Diploma thesis: Comparison of selected sensorimotor abilities in individuals with and without haemophilia before and after six months of exercise therapy (2003) - Doctoral scholarship, Faculty of Social and Behavioural Sciences, Friedrich Schiller University Jena (2003–2012)
- Doctor of Philosophy (Dr. phil.), Friedrich Schiller University Jena
Dissertation: Physical fitness in children and adolescents with haemophilia
Grade: summa cum laude (2012) - Postdoctoral Researcher in Clinical Exercise Physiology, Department of Sports Medicine and Health Promotion, Institute of Sport Science, Friedrich Schiller University Jena (since 2015)
- Postdoctoral Researcher, Department of Psychosomatic Medicine and Psychotherapy, Jena University Hospital (since 2022)
- Previous research position
Research Assistant at the Department of Prevention, Rehabilitation and Sports Medicine, Technical University of Munich, then headed by Professor Dieter Jeschke. During this period, he conducted research for his diploma thesis. (January 1999 - October 2000) - Awards
- Award for the best final examination, Institute of Sport Science, Friedrich Schiller University Jena (2003)
- Best Poster Award, 40th German Congress of Sports Medicine, Cologne (2007)
- Best Poster Award in the category “Clinical Studies”, 42nd Haemophilia Symposium, Hamburg (2011)
Teaching
- Advanced Seminar in Sports Medicine (Module SPW-VSW1/VSW1a, Teacher Education Programme)
- Medical Diagnostics and Data Analysis in Sports and Exercise (Module SMED, M.Sc.)
- Sports Medicine Colloquium – Preparatory Module (Module SPW-VSW2-G/-R, Teacher Education Programme)
- Evidence-Based Exercise Practice – Sport Psychology and Sports Medicine (Module SBP, B.Sc.)
- Sports Medicine – Exercise and Training Physiology (Module NW-1 L(b), Teacher Education Programme)
Publications
- Geisler M, Herbsleb M, de la Cruz F, von Au S, Schumann A, Croy I, Bär KJ (2026). Profound neuronal differences during exercise-induced hypoalgesia between athletes and non-athletes revealed by functional near-infrared spectroscopy. J Physiol 604(7): 2738-2756. doi: 10.1113/JP289766
- Schrenk SJ, Bang C, Best L, Dost T, Flor S, Frahm C, Gaser C, Hamdan RA, Herbsleb M, Kaleta C, Kattlun F, Müller HJ, Puta C, Radscheidt M, Ruiz-Rizzo AL, Scherag A, Steidten T, Witte OW, Brodoehl S, Finke K (2026). Impact of an online-guided physical activity intervention on cognition, resting-state brain connectivity, and the gut microbiome in healthy older adults—a randomized controlled trial. GeroScience. Epub ahead of print. doi: 10.1007/s11357-026-02324-6
- Warneke K, Lebelt N, Liebermann F, Jöst B, Herbsleb M (2026). Reliability and device objectivity in oscillatory blood pressure measurement — a measurement error analysis to inform clinical decision making. BMC Cardiovasc Disord 26(1): 593. doi: 10.1186/s12872-026-06262-1
- Warneke K, Oraze M, Herbsleb M, Afonso J, Wallot S (2026). Do sex differences influence test habituation and internal data validity in neurocognitive testing? A blinded measurement error analysis. Neuroscience 593: 106-121. doi: 10.1016/j.neuroscience.2025.12.007
- Saraei T, Schrenk S, Puta C, Herbsleb M, Witte OW, Frahm C, Brodoehl S, Finke K, Gaser C (2025). Physical Activity and BrainAGE: Exploring the Impact on Brain Health and Plasticity in Older Adults. Human Brain Mapping 46(15): e70378. doi: 10.1002/hbm.70378
- Warneke K, Oraže M, Plöschberger G, Herbsleb M, Afonso J, Wallot S (2025). When Testing Becomes Learning — Underscoring the Relevance of Habituation to Improve Internal Validity of Common Neurocognitive Tests. European Journal of Neuroscience 61(8): e70117. doi: 10.1111/ejn.70117
- Geisler M, de la Cruz F, Makris N, Billah T, Zhang F, Rathi Y, O'Donnell LJ, Bouix S, Herbsleb M, Bär K-J, Kikinis Z, Weiss T (2024). Brains of endurance athletes differ in the association areas but not in the primary areas. Psychophysiology 61: e14483. doi: 10.1111/psyp.14483
- Schrenk SJ, Brodoehl S, Flor S, Frahm C, Gaser C, Hamdan RA, Herbsleb M, Kaleta C, Kattlun F, Müller HJ, Puta C, Radscheidt M, Ruiz-Rizzo AL, Saraei T, Scherag A, Steidten T, Witte OW, Finke K (2023). Impact of an online guided physical activity training on cognition and gut-brain axis interactions in older adults: protocol of a randomized controlled trial. Front Aging Neurosci 15: 1254194. doi: 10.3389/fnagi.2023.1254194
- de la Cruz F, Geisler M, Schumann A, Herbsleb M, Kikinis Z, Weiss T, Bär KJ (2022). Central autonomic network alterations in male endurance athletes. Scientific Reports 12: 16743. doi: 10.1038/s41598-022-20064-3
- Herbsleb M (2022). Bewegung ins Leben bringen – Sport und Depression. physiopraxis 20(07/08): 48-51. thieme-connect.com/products/ejournals/pdf/10.1055/a-1802-3235.pdf
- Herbsleb M (2022). Sporttherapie bei Depression. VPT Magazin 08(03): 16-18. doi: 10.1055/s-0042-1745926
- Herbsleb M, Ziezio R, Stanek FD, Donath L, Puta C (2022). Prävention von haltungs- und inaktivitätsbedingten Funktionsstörungen: Prinzipien und Übungsbeispiele. Muskuloskelettale Physiotherapie 26(02): 87-95. doi: 10.1055/a-1731-6947
- Geisler M, Ritter A, Herbsleb M, Bär K-J, Weiss T (2021). Neural mechanisms of pain processing differ between endurance athletes and nonathletes: A functional connectivity magnetic resonance imaging study. Human Brain Mapping: 1-16. doi: 10.1002/hbm.25659
- Geisler M, Rizzoni E, Makris N, Pasternak O, Rathi Y, Bouix S, Herbsleb M, Bär K-J, Weiss T, Kikinis Z (2021). Microstructural alterations in medial forebrain bundle are associated with interindividual pain sensitivity. Human Brain Mapping 42: 1130-1137. doi: 10.1002/hbm.25281
- Steidten T, Baumbach P, May R, Gabriel B, Herbsleb M, Markov A, Granacher U, Kellmann M, Bloch W, Gabriel HHW, Puta C (2021). Overnight Immune Regulation and Subjective Measures of Sleep: A Three Night Observational Study in Adolescent Track and Field Athletes. Front Sports Act Living 3: 689805. doi: 10.3389/fspor.2021.689805
- Herbsleb M, Schumann A, Lehmann L, Gabriel HHW, Bär KJ (2020). Cardio-Respiratory Fitness and Autonomic Function in Patients with Major Depressive Disorder. Front Psychiatry 10: 980. eCollection 2019. doi: 10.3389/fpsyt.2019.00980
- Scharschmidt R, Derlien S, Siebert T, Herbsleb M, Stutzig N (2020). Intraday and interday reliability of pelvic floor muscles electromyography in continent woman. Neurourol Urodyn 39: 271-278. doi: 10.1002/nau.24187
- Herbsleb M, Keller-Varady K, Wobrock T, Hasan A, Schmitt A, Falkai P, Gabriel HHW, Bär KJ, Malchow B (2019). The Influence of Continuous Exercising on Chronotropic Incompetence in Multi-Episode Schizophrenia. Frontiers in Psychiatry 10: 90. doi: 10.3389/fpsyt.2019.00090
- Kurz E, Herbsleb M, Gabriel HHW, Hilberg T (2019). Posturographic and ankle muscle activation characteristics in patients with haemophilia. Haemophilia 25: 136-143. doi: 10.1111/hae.13650
- Herbsleb M, Schumann A, Malchow B, Puta C, Schulze PC, Gabriel HW, Bär KJ (2018). Chronotropic incompetence of the heart is associated with exercise intolerance in patients with schizophrenia. Schizophrenia Research 197: 162-169. doi: 10.1016/j.schres.2018.02.020
- Puta C, Steidten T, Baumbach P, Wöhrl T, May R, Kellmann M, Herbsleb M, Gabriel B, Weber S, Granacher U, Gabriel HHW (2018). Standardized Assessment of Resistance Training-Induced Subjective Symptoms and Objective Signs of Immunological Stress Responses in Young Athletes. Frontiers in Physiology 9: 698. doi: 10.3389/fphys.2018.00698
- Weber S, Puta C, Lesinski M, Gabriel B, Steidten T, Bär KJ, Herbsleb M, Granacher U, Gabriel HHW (2018). Symptoms of Anxiety and Depression in Young Athletes Using the Hospital Anxiety and Depression Scale. Frontiers in Physiology 9: 182. doi: 10.3389/fphys.2018.00182
- Wagner G, Herbsleb M, Cruz F, Schumann A, Köhler S, Puta C, Gabriel HW, Reichenbach J R, Bär KJ (2017). Changes in fMRI activation in anterior hippocampus and motor cortex during memory retrieval after an intense exercise intervention. Biological Psychology 124: 65-78. doi: 10.1016/j.biopsycho.2017.01.003
- Abou Hamdan R, Schumann A, Herbsleb M, Schmidt M, Rose G, Bär K-J, Gabriel H (2016). Determining cardiac vagal threshold from short term heart rate complexity. Current Directions in Biomedical Engineering 2(1): 155-159. doi: 10.1515/cdbme-2016-0036
- Puta C, Weber S, May R, Steidten T, Hildebrandt P, Gabriel B, Herbsleb M, Lesinski M, Kellmann M, Granacher U, Gabriel H (2016). Immun-Score: Entwicklung eines benutzerfreundlichen Instruments zur standardisierten Erfassung von Symptomen für die Differenzierung von belastungsinduzierter und infektbasierter Stressreaktion im Nachwuchsleistungssport. Leistungssport 46(6): 15-18.
- Gabriel HHW, Herbsleb M, Puta C (2015). Sportmedizinische Grundlagen. In: V Markser, K-J Bär, editor. Sport- und Bewegungstherapie bei seelischen Erkrankungen: Forschungsstand und Praxisempfehlungen. Stuttgart: Schattauer. pp. 47-54.
- Herbsleb M, Puta C (2015). Grundlagen der Trainingslehre. In: V Markser, K-J Bär, editor. Sport- und Bewegungstherapie bei seelischen Erkrankungen: Forschungsstand und Praxisempfehlungen. Stuttgart: Schattauer. pp. 36-46.
- Wagner G, Herbsleb M, de la Cruz F, Schumann A, Brünner F, Schachtzabel C, Gussew A, Puta C, Smesny S, Gabriel HW, Reichenbach J R, Bär KJ (2015). Hippocampal structure, metabolism, and inflammatory response after a 6-week intense aerobic exercise in healthy young adults: a controlled trial. Journal of Cerebral Blood Flow & Metabolism 35(10): 1570-1578. doi: 10.1038/jcbfm.2015.125
- Herbsleb M, Mühlhaus T, Bär KJ (2014). Differential cardiac effects of aerobic interval training versus moderate continuous training in a patient with schizophrenia: a case report. Front Psychiatry 5: 119. doi: 10.3389/fpsyt.2014.00119
- Puta C, Herbsleb M (2014). Training der motorischen Grundeigenschaften. In: H-D Kempf, editor. Die Neue Rückenschule. Ein Praxishandbuch. Berlin, Heidelberg: Springer-Verlag, 2. Auflage. pp. 217-244.
- Herbsleb M, Schulz S, Ostermann S, Donath L, Eisenträger D, Puta C, Voss A, Gabriel HW, Bär KJ (2013). The relation of autonomic function to physical fitness in patients suffering from alcohol dependence. Drug Alcohol Depend 132(3): 505-512. doi: 10.1016/j.drugalcdep.2013.03.016
- Ostermann S, Herbsleb M, Schulz S, Donath L, Berger S, Eisenträger D, Siebert T, Müller HJ, Puta C, Voss A, Gabriel HW, Koch K, Bär KJ (2013). Exercise reveals the interrelation of physical fitness, inflammatory response, psychopathology, and autonomic function in patients with schizophrenia. Schizophr Bull 39(5): 1139-1149. doi: 10.1093/schbul/sbs085
- Bär K-J, Herbsleb M, Schulz S, Rachow T, Eisenträger D, Puta C, Gabriel H, Voss A (2012). Physical fitness and autonomic dysbalance in schizophrenia. Biomed Tech (Berl) 57.
- Herbsleb M, Abou-Hamdan R, Puta C, Donath L, Kobelt R, Stanek FD, Hilberg T, Gabriel HHW (2012). Schwere und mittelschwere Hämophilie unter prophylaktischer Substitutionstherapie: Maximale Drehmomente der Knieextensoren und Knieflexoren bei Kindern und Jugendlichen. Hamostaseologie 32 Suppl 1: S62-69. PMID: 22961403
- Herbsleb M, Donath L, Hamdan R, Puta C, Kobelt R, Hilberg T, Gabriel H (2012). Is there a link between aerobic capacity and behavioural attributes in children with haemophilia? A pilot study. 43rd Hemophilia Symposium. Hamburg.
- Kurz E, Anders C, Herbsleb M, Puta C, Czepa D, Hilberg T (2012). Ankle muscle activation in people with haemophilia. Haemophilia 18 (6): 948-954. doi: 10.1111/j.1365-2516.2012.02852.x
- Kurz E, Herbsleb M, Anders C, Czepa D, Puta C, Hilberg T (2012). Concurrent and synergistic activation of selected muscles of severely affected haemophilic ankle joints during bipedal standing. Acta Physiol 204(689).
- Bär KJ, Herbsleb M, Eisenträger D, Berger S, Schulz S, Voss A, Puta C, Gabriel H (2011). Störung von Atemregulation sowie kardialer Kontrolle während körperlicher Belastung bei Patienten mit paranoider Schizophrenie. Posterpräsentation auf der Jahrestagung der Deutschen Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde (DGPPN). pp. P006.
- Herbsleb M, Hamdan R, Puta C, Donath L, Kobelt R, Hilberg T, Gabriel H (2011). Maximale Drehmomente der Knieextensoren und Knieflexoren von Kindern und Jugendlichen mit schwerer und mittelschwerer Hämophilie unter prophylaktischer Substitutionstherapie. 42 Hämophilie-Symposion. Hamburg.
- Herbsleb M, Puta C, Oswald K, Donath L, Kobelt R, Hilberg T, Gabriel H (2011). Statisches Gleichgewichtsverhalten und Standregulation von Kindern und Jugendlichen mit schwerer und mittelschwerer Hämophilie unter prophylaktischer Substitutionstherapie. 42 Hämophilie-Symposion. Hamburg.
- Kurz E, Herbsleb M, Anders C, Czepa D, Puta C, Hilberg T (2011). Different functional surfaces alter knee muscle activation levels during bipedal standing in healthy subjects - methodological aspects for sensory-motor programs. Physiotherapy 97: eS646.
- Kurz E, Herbsleb M, Anders C, Czepa D, Puta C, Hilberg T (2011). Aktivierungsstrategien von Muskeln des Sprunggelenkes in Abhängigkeit visueller Deprivation bei Patienten mit Hämophilie. Deutsche Zeitschrift für Sportmedizin 62: 253, R 301.
- Kurz E, Herbsleb M, Anders C, Graßme R, Czepa D, Puta C, Hilberg T (2011). Spektralanalyse von Sprunggelenkmuskeln im Stand auf hartem und weichem Untergrund bei Patienten mit Hämophilie. Deutsche Zeitschrift für Sportmedizin 62: 208, R 124.
- Kurz E, Herbsleb M, Anders C, Puta C, Vollandt R, Czepa D, Ziezio R, Scholle HC, Hilberg T (2011). SEMG activation patterns of thigh muscles during upright standing in haemophilic patients. Haemophilia 17 (4): 669-675. doi: 10.1111/j.1365-2516.2010.02466.x
- Puta C, Herbsleb M, Weiss T, Gabriel H (2011). Rückenschmerz - Schmerzverarbeitung und aktive segmentale Stabilisation. Aktuelle Aspekte der "neuen Rückenschule". Manuelle Medizin 49: 83-90. doi: 10.1007/s00337-011-0818-y
- Wick C, Puta C, Herbsleb M, Töpper A (2011). Gesundheitstraining Haltungs- und Bewegungssystem. In: L Vogt, A Neumann, editor. Sport in der Prävention: Handbuch für Übungsleiter, Sportlehrer, Physiotherapeuten und Trainer. Köln: Deutscher Ärzteverlag. pp. 129-169.
- Donath L, Puta C, Nötzel D, Herbsleb M, Müller HJ, Glaser A, Gabriel HHW (2010). Zunehmende Fluktuation der Laktat-Steady-States am Ende der Belastungsstufen: Konsequenzen für die Laktatleistungsdiagnostik? In: Wollesen KMB, editor. Bewegung und Leistung - Sport, Gesundheit und Alter. Hamburg: 8. Gemeinsames Symposium der dvs-Sektionen Biomechanik, Sportmotorik und Trainingswissenschaft 02.-04. September 2010, Schriften der Deutschen Vereinigung für Sportwissenschaft. pp. 78.
- Kurz E, Herbsleb M, Anders C, Czepa D, Puta C, Ziezio R, Scholle HC, Hilberg T (2010). Haemophilia & Exercise Project (HEP): Synergism and antagonism of selected knee muscles in haemophilic patients. 54 Jahrestagung der Gesellschaft für Thrombose und Hämostaseforschung (GTH). Hämostaseologie 30: A59, P06-11.
- Puta C, Herbsleb M (2010). Training der motorischen Grundeigenschaften. In: Kempf HD, editor. Die Neue Rückenschule: Das Praxisbuch. Heidelberg: Springer Medizin Verlag. pp. 141-161.
- von Mackensen S, Czepa D, Herbsleb M, Hilberg T (2010). Development and validation of a new questionnaire for the assessment of subjective physical performance in adult patients with haemophilia — the HEP-Test-Q. Haemophilia 16(1): 170-178. doi: 10.1111/j.1365-2516.2009.02112.x
- Donath L, Nötzel D, Puta C, Sölter F, Herbsleb M, Müller HJ, Gabriel HHW (2009). Über den Einfluss des Respiratorischen Quotienten vor Beginn eines Stufentests auf den Grad der Ausbelastung und den Anteil der Fettverbrennung in der Nachbelastungsphase. Deutsche Zeitschrift für Sportmedizin 60: 192.
- Herbsleb M, Hilberg T (2009). Maximal and submaximal endurance performance in adults with severe haemophilia. Haemophilia 15(1): 114-121. doi: 10.1111/j.1365-2516.2008.01860.x
- Kurz E, Herbsleb M, Anders C, Czepa D, Puta C, Ziezio R, Scholle HC, Hilberg T (2009). Haemophilia and Exercise Project (HEP): Elektromyographische Untersuchung ausgewählter Muskeln des hämophilen Kniegelenks nach einjähriger programmierter Sporttherapie. Deutsche Zeitschrift für Sportmedizin 60: 205.
- Kurz E, Herbsleb M, Anders C, Czepa D, Puta C, Ziezio R, Scholle HC, Hilberg T (2009). Haemophilia and Exercise Project (HEP): Muscle activation patterns of selected ankle muscles in haemophilic patients during bipedal upright standing depending on orthopaedic joint score. Acta Physiologica 195: 100.
- Kurz E, Herbsleb M, Anders C, Czepa D, Puta C, Ziezio R, Scholle HC, Hilberg T (2009). Haemophilia and Exercise Project (HEP): Activity of selected ankle muscles in haemophilic patients during bipedal standing depending on orthopaedic joint score. Hamostaseologie 29: A41.
- Kurz E, Herbsleb M, Anders C, Czepa D, Puta C, Ziezio R, Scholle HC, Hilberg T (2009). Haemophilia and Exercise Project (HEP): Co-activation of selected knee muscles in haemophilic patients. Hamostaseologie 29: A38.
- Herbsleb M, Puta C, Hilberg T (2008). Conception and contents of an "Programmed Sports Therapy" for Hemophilic patients. In: I Scharrer WS, editor. 37th Hemophilia Symposium Hamburg 2006: Springer Berlin pp. 45-59.
- Kempf H-D, Puta C, Herbsleb M (2008). Stabilisationsübungen in der Rückenschule mit dem Propriomed. Die Säule 18: 173-179.
- Kurz E, Herbsleb M, Anders C, Czepa D, Puta C, Ziezio R, Scholle HC, Hilberg T (2008). Haemophilia and Exercise Project (HEP): Muscle activation patterns of selected knee muscles in haemophilic patients depending on orthopaedic joint score. Hamostaseologie 28: A109.
- Herbsleb M, Puta J, Czepa D, Puta C, Hilberg T (2007). Haemophilia & Exercise Project (HEP): Auswirkungen einer zweijährigen programmierten Sporttherapie auf die isometrische Maximalkraft der unteren Extremitäten bei Erwachsenen mit Hämophilie. Deutsche Zeitschrift für Sportmedizin 58: S204.
- Kurz E, Herbsleb M, Anders C, Czepa D, Puta C, Ziezio R, Scholle HC, Hilberg T (2007). Haemophilia and Exercise Project (HEP): Aktivierungsverhalten ausgewählter Muskeln des hämophilen Kniegelenks im aufrechten Stand unter Berücksichtigung des Gelenkstatus. Deutsche Zeitschrift für Sportmedizin 58: S226.
- Kurz E, Herbsleb M, Puta C, Anders C, Scholle HC, Ziezio R, Czepa D, Hilberg T (2007). Electromyography of selected muscles in the haemophilic knee. Hamostaseologie 27: A65.
- Herbsleb M, Hilberg T, Puta C, Gabriel HHW (2005). Ausdauerleistungsfähigkeit erwachsener Personen mit Hämophilie. Deutsche Zeitschrift für Sportmedizin 56: 289.
- Herbsleb M, Hilberg T, Puta J, Puta C, Gabriel HHW (2005). Quantifizierung der isometrischen Maximalkraft und des bilateralen Kraftdefizits bei erwachsenen Personen mit Hämophilie. Deutsche Zeitschrift für Sportmedizin 56: 288.
- Hilberg T, Herbsleb M, Puta C, Czepa D, Gothe D, Gabriel HHW (2005). Veränderungen der gesundheitsbezogenen Lebensqualität durch Sporttherapie bei Personen mit schwerer Hämophilie A bzw. B. Deutsche Zeitschrift für Sportmedizin 56: 195.
- Hilberg T, Herbsleb M, Koch C, Puta C, Schramm W (2003). Sportcamp für Hämophile: Möglichkeiten der Sporttherapie. Deutsche Zeitschrift für Sportmedizin 54: S96.
- Hilberg T, Herbsleb M, Puta C, Gabriel HH, Schramm W (2003). Physical training increases isometric muscular strength and proprioceptive performance in haemophilic subjects. Haemophilia 9(1): 86-93. doi: 10.1046/j.1365-2516.2003.00679.x
- Hilberg T, Herbsleb M, Puta C, Gabriel H, Schramm W (2002). Körperliches Training steigert die isometrische Muskelkraft und sensomotorische Fähigkeiten bei hämophilen Personen. Deutsche Zeitschrift für Sportmedizin 53: 281-287.
- Hilberg T, Herbsleb M, Gabriel HH, Jeschke D, Schramm W (2001). Proprioception and isometric muscular strength in haemophilic subjects. Haemophilia 7(6): 582-588. doi: 10.1046/j.1365-2516.2001.00563.x
- Hilberg T, Herbsleb M, Puta C, Gabriel HHW, Schramm W (2001). Proprioception in subjects with and without hemophilia -Hemophilia & Exercise Project. Annals of Hematology 80: A26.
Miriam Ringleb
PhD Student
Exercise scientist specializing in exercise immunology. As a PhD researcher at German Sport University Cologne, she investigates the acute and chronic effects of exercise on immune cells and exerkines, with a focus on genetic, epigenetic, and physiological adaptations. Her work combines advanced immunological laboratory techniques to better understand how exercise influences the immune system in both healthy individuals and clinical populations, including post-COVID condition, depression, and obesity.
Publications
- Ringleb M, Bizjak DA, Nieß AM, Notbohm H, Predel H-G, Puta C, Steinacker JM, Widmann M, Zacher J, Bloch W, Javelle F (2026). Immune Dysregulation and Persistent Symptoms: Insights into T Cell Dynamics in Post-COVID among Athletes from the CoSmo-S Study. Journal of Clinical Immunology. doi: 10.1007/s10875-026-02020-2
- Ringleb M, Fabritius F, Godde J, Puta C, Bloch W, Javelle F (2026). Circulating Myokine Responses to Acute Endurance Exercise and Their Role in Immunoregulation: A Systematic Review and Meta-Analysis. The FASEB Journal 40(4): e71536. doi: 10.1096/fj.202504780R
- Christ T, Ringleb M, Haunhorst S, Fennen L, Jordan PM, Wagner H, Puta C (2024). The acute effects of pre- and mid-exercise carbohydrate ingestion on the immunoregulatory stress hormone release in experienced endurance athletes — a systematic review. Frontiers in Sports and Active Living 6: 1264814. doi: 10.3389/fspor.2024.1264814
- Ringleb M, Javelle F, Haunhorst S, Bloch W, Fennen L, Baumgart S, Drube S, Reuken PA, Pletz MW, Wagner H, Gabriel HHW, Puta C (2024). Beyond muscles: Investigating immunoregulatory myokines in acute resistance exercise – A systematic review and meta-analysis. The FASEB Journal 38(7): e23596. doi: 10.1096/fj.202301619R
- Haunhorst S, Bloch W, Ringleb M, Fennen L, Wagner H, Gabriel HHW, Puta C (2022). Acute effects of heavy resistance exercise on biomarkers of neuroendocrine-immune regulation in healthy adults: a systematic review. Exerc Immunol Rev 28: 36-52. eir-isei.de/2022/eir-2022-036-article.pdf
Rami Abou Hamdan
PostDoc · Lab Assistant
Sport scientist with a focus on heart rate variability, performance diagnostics and recovery.
Bio
- Diploma studies in Sport Science, Tishreen University, Latakia (2000–2004)
- Physical education teacher, Damascus Governorate (2004–2006)
- Supplementary studies, Diploma of Education, Damascus University (2005–2007)
- Sport scientist, Faculty of Sport Science, Tishreen University, Latakia (2006–2008)
- German language course, Saarland University (10/2008–04/2009)
- Doctoral student and research associate, Department of Sports Medicine and Health Promotion, Friedrich Schiller University Jena (since 05/2009)
Teaching
- Involved in teaching at the Department of Sports Medicine and Health Promotion, Friedrich Schiller University Jena (since 10/2011)
Publications
- Schrenk SJ, Bang C, Best L, Dost T, Flor S, Frahm C, Gaser C, Hamdan RA, Herbsleb M, Kaleta C, Kattlun F, Müller HJ, Puta C, Radscheidt M, Ruiz-Rizzo AL, Scherag A, Steidten T, Witte OW, Brodoehl S, Finke K (2026). Impact of an online-guided physical activity intervention on cognition, resting-state brain connectivity, and the gut microbiome in healthy older adults—a randomized controlled trial. GeroScience. Epub ahead of print. doi: 10.1007/s11357-026-02324-6
- Schrenk SJ, Brodoehl S, Flor S, Frahm C, Gaser C, Hamdan RA, Herbsleb M, Kaleta C, Kattlun F, Müller HJ, Puta C, Radscheidt M, Ruiz-Rizzo AL, Saraei T, Scherag A, Steidten T, Witte OW, Finke K (2023). Impact of an online guided physical activity training on cognition and gut-brain axis interactions in older adults: protocol of a randomized controlled trial. Front Aging Neurosci 15: 1254194. doi: 10.3389/fnagi.2023.1254194
- Stallmach A, Katzer K, Besteher B, Finke K, Giszas B, Gremme Y, Abou Hamdan R, Lehmann-Pohl K, Legen M, Lewejohann JC, Machnik M, Moshmosh Alsabbagh M, Nardini L, Puta C, Stallmach Z, Reuken PA (2022). Mobile primary care for post-COVID patients in rural areas: a proof-of-concept study. Infection 13: 1-9. doi: 10.1007/s15010-022-01881-0
- Abou Hamdan R, Schumann A, Herbsleb M, Schmidt M, Rose G, Bär K-J, Gabriel H (2016). Determining cardiac vagal threshold from short term heart rate complexity. Current Directions in Biomedical Engineering 2(1): 155-159. doi: 10.1515/cdbme-2016-0036
- Nothnagel H, Abou-Hamdan R, Zeh S, Bär KJ, Gabriel H, Puta C (2013). Effekte kutaner punktueller schmerzhafter mechanischer Stimuli am unteren Rücken auf die Herzrate bei Personen ohne chronische Rückenschmerzen. Der Schmerz 27: 122.
- Herbsleb M, Abou-Hamdan R, Puta C, Donath L, Kobelt R, Stanek FD, Hilberg T, Gabriel HHW (2012). Schwere und mittelschwere Hämophilie unter prophylaktischer Substitutionstherapie: Maximale Drehmomente der Knieextensoren und Knieflexoren bei Kindern und Jugendlichen. Hamostaseologie 32 Suppl 1: S62-69. PMID: 22961403
- Herbsleb M, Donath L, Hamdan R, Puta C, Kobelt R, Hilberg T, Gabriel H (2012). Is there a link between aerobic capacity and behavioural attributes in children with haemophilia? A pilot study. 43rd Hemophilia Symposium. Hamburg.
- Herbsleb M, Hamdan R, Puta C, Donath L, Kobelt R, Hilberg T, Gabriel H (2011). Maximale Drehmomente der Knieextensoren und Knieflexoren von Kindern und Jugendlichen mit schwerer und mittelschwerer Hämophilie unter prophylaktischer Substitutionstherapie. 42 Hämophilie-Symposion. Hamburg.
Sebastian Kirschke
PhD Student · SynoSys.PC project
sebastian.kirschke@med.uni-jena.de
Sport scientist working on the development and analysis of clinical databases of patients with post-infectious conditions. Contributes to the phenotyping of ME/CFS and Long COVID using physiological and immunological data. Also has practical experience in orthopedic rehabilitation, including knee and hip replacement and ACL reconstruction, with a focus on return-to-sport testing.
Publications
- Röhr W, Simon R, Kirschke S, von Loga I, Putrino D, Bloch W, Reuken PA, Dudziak D, Kipp AP, Stallmach A, Puta C (2026). Acute effects of the 1-minute sit-to-stand test (STST) on immune-metabolic stress indices. Sci Rep 16(1): 25484. doi: 10.1038/s41598-026-66330-6
Simon Haunhorst
Research Assistant · PostDoc · SynoSys.PC/Bio-Sig PEM project
Sport scientist and medical student. Simon received his PhD from the Friedrich Schiller University Jena exploring pathophysiological aspects of post-acute infection syndromes (e.g. Long COVID, ME/CFS) in the context of the immunobiology of physical exercise. He is currently following up on this research at the Department of Internal Medicine IV with particular focus on post-exertional symptom exacerbations (i.e. PEM).
Publications
- Steidten T, Granacher U, Gabriel H, Haunhorst S, Reuken P, Dudziak D, Puta C (2025). Impact of different concurrent training sequencing schemes on overnight systemic immunological regulation in adolescent athletes. Frontiers in Physiology 16: 1392946. doi: 10.3389/fphys.2025.1392946
- Christ T, Ringleb M, Haunhorst S, Fennen L, Jordan PM, Wagner H, Puta C (2024). The acute effects of pre- and mid-exercise carbohydrate ingestion on the immunoregulatory stress hormone release in experienced endurance athletes — a systematic review. Frontiers in Sports and Active Living 6: 1264814. doi: 10.3389/fspor.2024.1264814
- Haunhorst S, Dudziak D, Scheibenbogen C, Seifert M, Sotzny F, Finke C, Behrends U, Aden K, Schreiber S, Brockmann D, Burggraf P, Bloch W, Ellert C, Ramoji A, Popp J, Reuken P, Walter M, Stallmach A, Puta C (2024). Towards an understanding of physical activity-induced post-exertional malaise: Insights into microvascular alterations and immunometabolic interactions in post-COVID condition and myalgic encephalomyelitis/chronic fatigue syndrome. Infection 53: 1-13. doi: 10.1007/s15010-024-02386-8
- Ringleb M, Javelle F, Haunhorst S, Bloch W, Fennen L, Baumgart S, Drube S, Reuken PA, Pletz MW, Wagner H, Gabriel HHW, Puta C (2024). Beyond muscles: Investigating immunoregulatory myokines in acute resistance exercise – A systematic review and meta-analysis. The FASEB Journal 38(7): e23596. doi: 10.1096/fj.202301619R
- Haunhorst S, Bloch W, Drube S, Baumgart S, Pletz MW, Gabriel HHW, Puta C (2023). Current return to sports recommendations after non-severe COVID-19 from an exercise immunology perspective: A scoping review. Sport Orthopaedics and Traumatology 39(4): 378-388. doi: 10.1016/j.orthtr.2023.11.003
- Haunhorst S, Bloch W, Puta C (2023). Impact Of Long Covid On Recovery In Sport and Exercise. The Importance of Recovery for Physical and Mental Health, 1st Edition, Routledge: 203-222. doi: 10.4324/9781003250647-12
- Haunhorst S, Bloch W, Puta C (2023). 8 Recovery and the immune system. In: M Kellmann, S Jakowski, J Beckmann (eds). The Importance of Recovery for Physical and Mental Health: Negotiating the Effects of Underrecovery. Routledge, Oxon. doi: 10.4324/9781003250647-8
- Palmowski J, Kohnhorst S, Bauer P, Puta C, Haunhorst S, Gebhardt K, Reichel T, Keller C, Huber M, Raifer H, Krüger K (2023). T-cell-derived TNF-α and a cluster of immunological parameters from plasma allow a separation between SARS-CoV-2 convalescent versus vaccinated elite athletes. Front Physiol 14: 1203983. doi: 10.3389/fphys.2023.1203983
- Haunhorst S, Bloch W, Ellert C, Puta C (2022). Recovered, but not healthy – Long Covid and the effects on physical performance. Sportphysio 10(03): 111-116. doi: 10.1055/a-1841-8209
- Haunhorst S, Bloch W, Javelle F, Krüger K, Baumgart S, Drube S, Lemhöfer C, Reuken P, Stallmach A, Müller M, Zielinski CE, Pletz MW, Gabriel HHW, Puta C (2022). A scoping review of regulatory T cell dynamics in convalescent COVID-19 patients – indications for their potential involvement in the development of Long COVID? Front Immunol 13: 1070994. doi: 10.3389/fimmu.2022.1070994
- Haunhorst S, Bloch W, Ringleb M, Fennen L, Wagner H, Gabriel HHW, Puta C (2022). Acute effects of heavy resistance exercise on biomarkers of neuroendocrine-immune regulation in healthy adults: a systematic review. Exerc Immunol Rev 28: 36-52. eir-isei.de/2022/eir-2022-036-article.pdf
- Haunhorst S, Bloch W, Wagner H, Ellert C, Krüger K, Vilser DC, Finke K, Reuken P, Pletz MW, Stallmach A, Puta C (2022). Long COVID: a narrative review of the clinical aftermaths of COVID-19 with a focus on the putative pathophysiology and aspects of physical activity. Oxford Open Immunology 3(1): iqac006. doi: 10.1093/oxfimm/iqac006
- Puta C, Haunhorst S, Bloch W (2021). Post-acute Covid-19 (“Long-covid”): Persistent symptoms, possible causes and symptom-driven post-acute Covid-19 management to regain physical performance (Scoping Review). Sports Orthopaedics and Traumatology 37(3): 214-225. doi: 10.1016/j.orthtr.2021.08.006
Sina Pappe
Lab Assistant
Short biography to be added.
Steffen Koster
Physician · Bio-Sig PEM project
Short biography to be added.
Thomas Steidten
PostDoc · SynoSys.PC project
Postdoctoral Researcher at the University Hospital Jena, leading the educational component of the SYNOSYS.PC project (since 2025). His work focuses on bridging the gap between theory and clinical practice, specifically designing knowledge transfer for both patients and physicians. Previously, he was a research associate at the Chair of Sports Medicine and Health Promotion (2016–2025) within the KINGS project. PhD (Dr. phil.) awarded in 2022. Research focus: immunological monitoring of exercise-induced stress and recovery, and evidence-based implementation in healthcare.
Publications
- Schrenk SJ, Bang C, Best L, Dost T, Flor S, Frahm C, Gaser C, Hamdan RA, Herbsleb M, Kaleta C, Kattlun F, Müller HJ, Puta C, Radscheidt M, Ruiz-Rizzo AL, Scherag A, Steidten T, Witte OW, Brodoehl S, Finke K (2026). Impact of an online-guided physical activity intervention on cognition, resting-state brain connectivity, and the gut microbiome in healthy older adults—a randomized controlled trial. GeroScience. Epub ahead of print. doi: 10.1007/s11357-026-02324-6
- Steidten T, Granacher U, Gabriel H, Haunhorst S, Reuken P, Dudziak D, Puta C (2025). Impact of different concurrent training sequencing schemes on overnight systemic immunological regulation in adolescent athletes. Frontiers in Physiology 16: 1392946. doi: 10.3389/fphys.2025.1392946
- Markov A, Bussweiler J, Helm N, Arntz F, Steidten T, Krohm L, Sacot A, Baumert P, Puta C, Chaabene H (2023). Acute effects of concurrent muscle power and sport-specific endurance exercises on markers of immunological stress response and measures of muscular fitness in highly trained young male athletes. Eur J Appl Physiol 123(5): 1015-1026. doi: 10.1007/s00421-022-05126-8
- Schrenk SJ, Brodoehl S, Flor S, Frahm C, Gaser C, Hamdan RA, Herbsleb M, Kaleta C, Kattlun F, Müller HJ, Puta C, Radscheidt M, Ruiz-Rizzo AL, Saraei T, Scherag A, Steidten T, Witte OW, Finke K (2023). Impact of an online guided physical activity training on cognition and gut-brain axis interactions in older adults: protocol of a randomized controlled trial. Front Aging Neurosci 15: 1254194. doi: 10.3389/fnagi.2023.1254194
- Puta C, Steidten T, Fischer S (2021). Overarm throwing in humans. In: R Schleip, J Willke, A Baker (Hrsg.). Fascia in Sports and Movement (2 ed.). Handspring Publishing Ltd. pp. 385-392.
- Steidten T, Baumbach P, May R, Gabriel B, Herbsleb M, Markov A, Granacher U, Kellmann M, Bloch W, Gabriel HHW, Puta C (2021). Overnight Immune Regulation and Subjective Measures of Sleep: A Three Night Observational Study in Adolescent Track and Field Athletes. Front Sports Act Living 3: 689805. doi: 10.3389/fspor.2021.689805
- Steidten T, Puta C (2020). Narratives Review zur Wirksamkeit von Faszientechniken. In: I Dienstbühl, M Stadeler, C Puta (Hrsg). 26. Erfurter Tage: Prävention von Arbeitsbedingten Gesundheitsgefahren und Erkrankungen. Jena: Dr. Bussert & Stadeler. pp. 201-208.
- Puta C, Steidten T, Baumbach P, Wöhrl T, May R, Kellmann M, Herbsleb M, Gabriel B, Weber S, Granacher U, Gabriel HHW (2018). Standardized Assessment of Resistance Training-Induced Subjective Symptoms and Objective Signs of Immunological Stress Responses in Young Athletes. Frontiers in Physiology 9: 698. doi: 10.3389/fphys.2018.00698
- Steidten T, Puta C, Gabriel B, May R, Kellmann M, Granacher U, Gabriel HHW (2018). Belastungsinduzierte immunologische Stressreaktion: How much is too much? Leistungssport, 48(5): 22-24.
- Weber S, Puta C, Lesinski M, Gabriel B, Steidten T, Bär KJ, Herbsleb M, Granacher U, Gabriel HHW (2018). Symptoms of Anxiety and Depression in Young Athletes Using the Hospital Anxiety and Depression Scale. Frontiers in Physiology 9: 182. doi: 10.3389/fphys.2018.00182
- Puta C, Weber S, May R, Steidten T, Hildebrandt P, Gabriel B, Herbsleb M, Lesinski M, Kellmann M, Granacher U, Gabriel H (2016). Immun-Score: Entwicklung eines benutzerfreundlichen Instruments zur standardisierten Erfassung von Symptomen für die Differenzierung von belastungsinduzierter und infektbasierter Stressreaktion im Nachwuchsleistungssport. Leistungssport 46(6): 15-18.
Wiebke Röhr
PhD Student · KIP project
Nutritional scientist specializing in sports medicine. Works on the characterization of immune-metabolic stress responses induced by anaerobic exercise, using the 1-minute sit-to-stand test as a standardized exercise test and capillary blood analyses. Focuses on immune cell dynamics, composite immune-stress indices, and alterations in lactate, glucose, and trace element concentrations.
Publications
- Röhr W, Simon R, Kirschke S, von Loga I, Putrino D, Bloch W, Reuken PA, Dudziak D, Kipp AP, Stallmach A, Puta C (2026). Acute effects of the 1-minute sit-to-stand test (STST) on immune-metabolic stress indices. Sci Rep 16(1): 25484. doi: 10.1038/s41598-026-66330-6
- Simon R, Röhr W, Schwarz M, Haase H, Puta C, Kipp AP (2026). Acute effects of physical exercise on biomarkers of the trace elements selenium, zinc, copper, and iron. Journal of Trace Elements in Medicine and Biology 94: 127828. doi: 10.1016/j.jtemb.2026.127828
Immunenotes